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M94A2916.TXT
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1994-10-25
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Document 2916
DOCN M94A2916
TI Stressful life events, cortisol and cellular immune changes in
asymptomatic, HIV infected individuals.
DT 9412
AU Petitto J; Lesserman J; Perkins D; Golden J; Folds J; Evans D; Univ. of
Florida, Gainesville 32610.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):195 (abstract no. PB0209). Unique
Identifier : AIDSLINE ICA10/94369659
AB Early HIV infection may produce functional changes in key
immunoregulatory cells including T helper cells and macrophages, cells
which may harbor the virus, as well as alter the numbers and function of
cytotoxic killer cells including NK cells and cytotoxic T cells. We have
employed both flow cytometric enumerative and functional immune assays
to begin to determine whether stressful life events may result in
changes in the phentotypic expression and function of several important
parameters of immune status. In asymptomatic HIV+ homosexual men, severe
life stressors correlated significantly with lower numbers of peripheral
blood cytotoxic/suppressor T cells, particularly those which express the
CD57 surface antigen. Reductions in both CD16+ and CD56+ NK cell
populations also correlated inversely with such stressors. Severe life
stressors did not correlate with T helper/inducer cell numbers or levels
of cytokines produced by macrophages/monocytes and T helper/inducer
cells. The most robust effects of stress were found among subjects
exhibiting high basal cortisol levels, whereas stress did not
significantly modify these immune measures in subjects with low basal
cortisol concentrations. These stress related alterations in killer
lymphocytes early in the course of infection may have relevance for the
progression of HIV diseases.
DE Human Hydrocortisone/*BLOOD HIV
Infections/BLOOD/COMPLICATIONS/*IMMUNOLOGY/PSYCHOLOGY Immunity,
Cellular Immunophenotyping Killer Cells, Natural/*IMMUNOLOGY
Leukocyte Count *Life Change Events Male *Neuroimmunomodulation
Stress, Psychological/BLOOD/COMPLICATIONS/*IMMUNOLOGY T-Lymphocyte
Subsets/*IMMUNOLOGY MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).